Evaluation of Fosfomycin and Laser in the Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Osteomyelitis in Rabbits

Document Type : Original Article

Authors

1 Lecturer of Oral Maxillofacial Radiology; Faculty of Dentistry , Bani-seuif University

2 Lecturer of Microbiology and Immunology ;Faculty of medicine, Misr university For science and technology

Abstract

Aim: to evaluate the effectiveness of fosfomycin and Diode laser treatment in experimental osteomyelitis induced by MRSA in rabbits.
Methods: Osteomylitis Infection was induced in the tibiae of thirty rabbits by the injection of a bacterial inoculum (7 x 106 CFU/ml) of a clinical MRSA isolate two weeks after infection, each animal was assigned to a treatment group: Group ( 1) include 10 animals were left untreated Group (2); Fosfomycin monotherapy at 75 mg/kg of body weight once daily (n_10), Group 3: (n = 10) rabbits were treated for 2 weeks with Diode laser 940 nm .After a 2-week treatment period, the animals were euthanized, and the infected tibiae were processed for quantitative bacterial cultures and bone density measurement .
RESULTS: bone culture from bone was positive for MRSA in all groups with no significant difference (p value <0.302). Based on bone density measurement; bone density was higher level at laser group followed by antibiotic FOF group then control group but there is no with significant difference p value Conclusion: The difference between laser group and fosfomycin group not significantly different between the two methods for modeling rabbit. However, histopathological method is recommended because it has certain increase confirmation which line of treatment was viald.

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