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Egyptian Dental Journal
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Volume Volume 67 (2021)
Volume Volume 66 (2020)
Issue Issue 4 - October (Orthodontics, Pediatric & Preventive Dentistry)
Issue Issue 4 - October (Oral Surgery)
Issue Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
Issue Issue 4 - October (Fixed Prosthodontics, Removable Prosthodontics and Dental Materials)
Issue Issue 4 - October (Conservative Dentistry and Endodontics)
Issue Issue 3 - July (Orthodontics, Pediatric & Preventive Dentistry)
Issue Issue 3 - ِJuly (Oral Surgery)
Issue Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
Issue Issue 3 - July (Fixed Prosthodontics, Removable Prosthodontics and Dental Materials)
Issue Issue 3 - July (Conservative Dentistry and Endodontics)
Issue Issue 2 - April (Orthodontics, Pediatric & Preventive Dentistry)
Issue Issue 2 - April (Oral Surgery)
Issue Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
Issue Issue 2 - April (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics)
Issue Issue 1 - January (Orthodontics, Pediatric & Preventive Dentistry)
Issue Issue 1 - January (Oral Surgery)
Issue Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)
Issue Issue 1 - January (Fixed Prosthodontics, Dental Materials, Conservative Dentistry & Endodontics)
Volume Volume 65 (2019)
Volume Volume 64 (2018)
Volume Volume 63 (2017)
Volume Volume 62 (2016)
Khalil, N., Nagui, D. (2020). Effect of Quercetin on filiform and fungiform papillae of the tongue of albino rats with induced diabetes. Egyptian Dental Journal, 66(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 197-211. doi: 10.21608/edj.2020.77535
Nesma Mohamed Khalil; Dina Ali Nagui. "Effect of Quercetin on filiform and fungiform papillae of the tongue of albino rats with induced diabetes". Egyptian Dental Journal, 66, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2020, 197-211. doi: 10.21608/edj.2020.77535
Khalil, N., Nagui, D. (2020). 'Effect of Quercetin on filiform and fungiform papillae of the tongue of albino rats with induced diabetes', Egyptian Dental Journal, 66(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 197-211. doi: 10.21608/edj.2020.77535
Khalil, N., Nagui, D. Effect of Quercetin on filiform and fungiform papillae of the tongue of albino rats with induced diabetes. Egyptian Dental Journal, 2020; 66(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 197-211. doi: 10.21608/edj.2020.77535

Effect of Quercetin on filiform and fungiform papillae of the tongue of albino rats with induced diabetes

Article 6, Volume 66, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), January 2020, Page 197-211  XML PDF (6.12 MB)
Document Type: Original Article
DOI: 10.21608/edj.2020.77535
Authors
Nesma Mohamed Khalil; Dina Ali Nagui
Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt
Abstract
Objective: The aim of the present work was to study the effect of Quercetin on the structure of filiform and fungiform papillae of the tongue in albino rats with streptozotocin induced diabetes.
Design: Thirty adult male Wistar rats were divided into 3 equal groups (10 rats each): Group 1 (control group), Group 2: (diabetic group) and Group 3: (Quercetin treated diabetic group). In both groups 2&3 diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg). After confirmation of diabetes, Quercetin was administrated to group 3 (50 mg/kg/day) orally for 12 weeks. Then all rats were sacrificed and the tongues were dissected out for light microscopic (LM) examination, immunohistochemical examination, histomorphometric analysis and scanning electron microscopic (SEM) examination.
Results: LM examination of diabetic group revealed disturbances in filiform papillae with hyperkeratosis. Fungiform papillae exhibited slight elongation with separation between taste bud cells. SEM examination revealed disturbance in the normal orientation of filiform papillae which appeared thin. On the other hand, in Quercetin treated group, there was marked improvement in the shape and orientation of the papillae. However, some changes were observed by LM which included hyperkeratosis and in SEM some filiform papillae appeared thin. Immunohistochemical analysis revealed strong reaction for caspase 3 in diabetic group, while in Quercetin treated group the reaction was mild. Quercetin treatment resulted in significant decrease in both area percentage of immunopositive cells and the optical density of caspase 3 immunostaining which was significantly increased after induction of diabetes.
Conclusions: In a rat model, Quercetin can to a great extent overcome most of the detrimental effects of diabetes on the structure of both filiform and fungiform papillae of the tongue.
Keywords
Quercetin; Caspase 3; diabetes; papillae
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