Background: Calcifying odontogenic cysts (COCs) are considered rare odontogenic lesions with a spectrum of behavioral and clinicopathological features. The rare Ghost cell odontogenic carcinoma (GCOC) is the malignant counterpart of (COC). The goal of this work was to study the expression NF-κB in COCs and GCOCs. Methods: NF-κB expression was evaluated in 8 (COCs) and 4 (GCOCs), using immunohistochemical method. Immunostaining was evaluated semi-quantitatively, following to the intensity and extent of staining. Results: B oth cytoplasmic and nuclear and NF-κB immunopositivity were detected in all COC tissues, as well as in GCOC. Conclusion: The expression of NF-κB may represent an important mechanism of tumor development and thus might have a role in the progression of ghost cell lesions.
)
View on SCiNiTO