Impact of antidepressant Duloxetine on the lingual mucosa of male albino rats (An ultrastructural, and imunohistoc hemical study)

Document Type : Original Article

Authors

1 Lecturer of Oral Biology Department, Faculty of Dentistry, Suez Canal University

2 Associated Professor of Oral Pathology Department, Faculty of Dentistry, Suez Canal University

Abstract

Objectives: This study was designed to clarify the effect of Duloxetine on the lingual mucosa
of male albino rats.
Materials and methods: Forty male albino rats divided as: 20 animals served as control.
Group II: 20 animals and received duloxetine in a dose of 10mg/kg body weight that dissolved in
distilled water and administrated through the metallic curved oropharngeal tube. At the end of the
experiments, which lasts for 3 months, half of the animals of different groups (group I.1 and II.1)
were sacrificed. The rest of animals (group I.2 and II .2) were allowed for a recovery period of 30
days. the tongue of all groups were extracted and prepared to examined through histological examination
of their lingual mucosa to detect any structural changes, transmission electron microscopic
examination of their lingual mucosa to detect any ultrastructural changes and immunohistochemical
localization of E-cadherin
Results: The light microscopic examination of the tongue of the rats treated with Duloxetine,
anti-depressant drug, showed degenerative changes that involved the surface epithelium and lamina
propria. The animals left for a recovery period showed partial improvement in their structure, these
results were indicated by ultrastructural results. The immunohistochemical results of Duloxetine
group showed weakly positive reactivity of E- cadherin while the recovery group showed moderately
positive reactivity to E cadherin.
Conclusion: Duloxetine has a degenerative effect upon the experimental level.
 

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