Artificial denture teeth are subjected to wear from daily masticatory functions. This wear affects the denture esthetics, functions and in turn results in patient discomfort. The purpose of this study was to evaluate the wear resistance of nano composite fabricated artificial denture teeth and conventional acrylic denture teeth reinforced with silica nano particles. A total number of 60 samples were used. Samples were divided into equal four groups (n=15). The first group was fabricated from nano filled composite. The second and third groups were silica nanoparticles modified acrylic denture teeth with two different concentrations 0.1% and 10% respectively. The fourth group was conventional acrylic resin denture teeth and served as a control. The 2-body wear testing was performed with a multi-modal ROBOTA chewing simulator. Wear was then evaluated by the means of weight loss and surface roughness. The nano-composite group recorded significantly higher wear resistance than conventional and silica modified acrylic resin groups. The silica modified acrylic resin group with 0.1% concentration recorded a lower surface roughness than any of the other groups. In conclusion; Nano-composite teeth can be used as artificial denture teeth exhibiting significant higher wear resistance than conventional and silica modified artificial acrylic teeth.