Evaluation of the prophylactic and therapeutic role of bone marrow mesenchymal stem cells injection on the affected tongue of 5- fluorouracil treated rats

Document Type : Original Article

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oral biology, faculty of dentistry, Beni Suef University

Abstract

Abstract:
Objectives: Chemotherapy induced stomatitis is considered one of the challenging factors that affect chemotherapy treatment coarse. So, this study was conducted to evaluate the possible role of intravenous injection of mesenchymal bone marrow stem cells (MBMSCs) in preventing or ameliorating the side effects of chemotherapy on the rat's tongue.
Methods: 40 rats were divided into: (G1): normal control group, (G2): chemotherapy group; injected with chemotherapy, (G3): prophylactic group; injected with chemotherapy and treated with stem cells before chemotherapy, (G4): therapeutic group; injected with chemotherapy then treated with stem cells. At day 8 all animals were sacrificed, the tongue was dissected. Examination of the dorsal and ventral surfaces of the tongue in addition to tongue muscles was performed.
Results: Only therapeutic gr. showed marked improvement of chemotherapy induced stomatitis which was manifested by increased epithelial thickness with numerous rete pigs, increased filliform papillae and increased mucosal proliferation rate. But chemotherapy induced muscle atrophy showed no improvement in both treated groups.
Conclusion: injection of MBMSCs has a therapeutic effect on chemotherapy induced mucosal atrophy. Also it was approved that, within a period of 8 days, stem cells have neither prophylactic nor therapeutic effect on chemotherapy induced lingual muscle atrophy.

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